The purpose of this research was to formulate and systematically evaluate the performances of mucoadhesive microspheres of midazolam. Midazolam microspheres containing gelatin alone and gelatin with chitosan were prepared by emulsion cross linking technique using glutaraldehyde as a cross-linking agent. Results of preliminary trials indicate that volume of cross-linking agent, time for cross-linking, polymer-to- polymer ratio and speed of rotation affected characteristics of microspheres. Microspheres were discrete, spherical, and free flowing. The microspheres exhibited good mucoadhesive and also showed high percentage drug entrapment efficiency. The best batch exhibited a high drug entrapment efficiency of 92.0% and a swelling index of 1.24; in vitro bioadhesion was 92.91%. The drug release was also sustained for 12 h. The polymer- to-drug ratio had a more significant effect.
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